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[Pathological characteristics and genetic background of renal cell carcinoma].

Magyar onkologia - 22 Apr 2023

Sánta Fanni, Pósfai Boglárka, Sejben Anita, Kuthi Levente

Abstract excerpt

Renal cell carcinoma (RCC) is the most common malignant kidney tumor. It is not a single entity but an umbrella term for several distinct tumor types. The most prevalent and clinically significant subtype of RCC is clear cell carcinoma, which consists of cells with empty cytoplasm. These tumor cells harbor biallelic loss of the VHL gene, resulting in a pseudohypoxic state that promotes angiogenesis and cellular...

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PMID: 37086452

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