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Article

Drug desensitization to lumacaftor/ivacaftor: A fast lane to drug tolerance.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Sept 2023

Westhoff J, Barth S, Naehrlich L

Abstract excerpt

We present the case of a girl (now 11 years and 9 months old) with cystic fibrosis (F508del homozygote), who developed pruritic rash and urticaria six days after the first dose of the CFTR modulators lumacaftor/ivacaftor. The treatment was paused and had to be interrupted due to an immediate recurrence of the urticarial rash after rechallenge. We developed a drug desensitization protocol, aligned to protocols...

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Identifiers

PMID: 37045685
DOI: 10.1016/j.jcf.2023.03.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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