Article
Effects of Genetic Polymorphisms of Drug Metabolizing Enzymes and co-Medications on Tamoxifen Metabolism in Black South African Women with Breast Cancer.
Clinical pharmacology and therapeutics - 1 Jul 2023
Chiwambutsa Shingirai M, Ayeni Oluwatosin, Kapungu Nyasha, Kanji Comfort, Thelingwani Roslyn, Chen Wenlong Carl, Mokone Dikeledi H, O'Neil Daniel S, Neugut Alfred I, Jacobson Judith S, Ruff Paul, Cubasch Herbert, Joffe Maureen, Masimirembwa Collen
Abstract excerpt
Clinical outcomes of tamoxifen (TAM) treatment show wide interindividual variability. Comedications and genetic polymorphisms of enzymes involved in TAM metabolism contributes to this variability. Drug-drug and drug-gene interactions have seldom been studied in African Black populations. We evaluated the effects of commonly co-administered medicines on TAM pharmacokinetics in a cohort of 229 South African Black...
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