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Article

Novel WFS1 mutations in patients with low-to-middle frequency hearing loss.

International journal of pediatric otorhinolaryngology - 1 Apr 2023

Guo Luo, Gu Xiaodong, Sun Qin, Zhang Yike, Li Huawei, Du Qiang

Abstract excerpt

BACKGROUND: Hearing loss (HL) is the most common sensorineural disorder in human. It is estimated that genetic factors contribute to over 50% of prelingual hearing loss. Most of dominant HHL patients manifest postlingual progressive hearing loss that mainly affect high frequencies. However, mutations in a few dominant HL genes, such as WFS1, TECTA and DIAPH1, cause distinct audiogram that primarily affects the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36958120
DOI: 10.1016/j.ijporl.2023.111484

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