Article
End-stage Hypertrophic Cardiomyopathy with Advanced Heart Failure in Patients Carrying MYH7 R453 Variants: A Case Series.
Internal medicine (Tokyo, Japan) - 1 Nov 2023
Naito Susumu, Higo Shuichiro, Kameda Satoshi, Ogawa Shou, Tabata Tomoka, Akazawa Yasuhiro, Nakamura Daisuke, Nakamoto Kei, Sera Fusako, Kuramoto Yuki, Asano Yoshihiro, Hikoso Shungo, Miyagawa Shigeru, Sakata Yasushi
Abstract excerpt
The MYH7 R453 variant has been identified in inherited hypertrophic cardiomyopathy (HCM) and is associated with sudden death and a poor prognosis. The detailed clinical course of HCM with the MYH7 R453 variant, from a preserved to a reduced left ventricular ejection fraction, has not been reported. We identified the MYH7 R453C and R453H variants in three patients who progressively developed advanced heart failure...
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