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Generation of induced pluripotent stem cells (IBMSi027-A) from a patient with hearing loss carrying WFS1 c.2051C > T (p.Ala684Val) variant.

Stem cell research - 1 Jun 2023

Chan Yen-Hui, Tsai Cheng-Yu, Ho Chang-Han, Lu Ying-Chang, Lin Pei-Hsuan, Chen Ta-Ching, Chen You-Tzung, Huang Cheng-Yen, Liu Tien-Chen, Hsu Chuan-Jen, Wu Chen-Chi

Abstract excerpt

Pathogenic variants of the WFS1 gene can cause recessive-inherited Wolfram syndrome or dominant-inherited Wolfram-like syndrome with optic atrophy and hearing impairment. Using the Sendai virus delivery system, we generated induced pluripotent stem cells from the peripheral blood mononuclear cells of a female patient with the WFS1 pathogenic variant c.2051C > T (p.Ala684Val). The resulting induced pluripotent...

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Hearing Loss
Induced Pluripotent Stem Cells
Leukocytes, Mononuclear
Mutation
Wolfram Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36933359
DOI: 10.1016/j.scr.2023.103068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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