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The use of copy number loads to designate mosaicism in blastocyst stage PGT-A cycles: fewer is better

16 Mar 2023

Abstract excerpt

STUDY QUESTION: How well can whole chromosome copy number analysis from a single trophectoderm (TE) biopsy predict true mosaicism configurations in human blastocysts? SUMMARY ANSWER: When a single TE biopsy is tested, wide mosaicism thresholds (i.e. 20-80% of aneuploid cells) increase false positive calls compared to more stringent ones (i.e. 30-70% of aneuploid cells) without improving true detection rate, while...

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PMID: 36928183
DOI: 10.1093/humrep/dead049

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