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Article

Multiple Fibroblast Subtypes Contribute to Matrix Deposition in Pulmonary Fibrosis

16 Mar 2023

Abstract excerpt

Abstract Progressive pulmonary fibrosis results from a dysfunctional tissue repair response and is characterized by fibroblast proliferation, activation, and invasion and extracellular matrix accumulation. Lung fibroblast heterogeneity is well recognized. With single-cell RNA sequencing, fibroblast subtypes have been reported by recent studies. However, the roles of fibroblast subtypes in effector functions in...

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Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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PMID: 36927333
DOI: 10.1165/rcmb.2022-0292oc

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