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The chaperone BiP promotes dengue virus replication and mosquito vitellogenesis in Aedes aegypti

13 Mar 2023

Abstract excerpt

Binding immunoglobulin protein (BiP, also known as GRP78), a chaperone and master regulator of the unfolded protein response (UPR) pathway, plays an essential role in several flavivirus infections, but its functional role in regulating dengue virus replication in the mosquito remains largely unknown. We here demonstrated the interaction between a dengue virus serotype 2 (DENV2) and BiP in Aedes aegypti and report...

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PMID: 36921733
DOI: 10.1016/j.ibmb.2023.103930

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