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Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment

7 Mar 2023

Abstract excerpt

The malaria parasite life cycle includes asexual replication in human blood, with a proportion of parasites differentiating to gametocytes required for transmission to mosquitoes. Commitment to differentiate into gametocytes, which is marked by activation of the parasite transcription factor ap2-g , is known to be influenced by host factors but a comprehensive model remains uncertain. Here, we analyze data from...

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PMID: 36916164
DOI: 10.7554/elife.85140

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