Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Potential Role of MiRs-139-5p and -454-3p in Endoglin-Knockdown-Induced Angiogenic Dysfunction in HUVECs

3 Mar 2023

Abstract excerpt

Hereditary hemorrhagic telangiectasia (HHT) is a rare genetic disease characterized by aberrant angiogenesis and vascular malformations. Mutations in the transforming growth factor beta co-receptor, endoglin (ENG), account for approximately half of known HHT cases and cause abnormal angiogenic activity in endothelial cells (ECs). To date, how ENG deficiency contributes to EC dysfunction remains to be fully...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pulmonary Hypertension Research and Treatments
Share to Tracheal and airway disorders
Share to Vascular Anomalies and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36902347
DOI: 10.3390/ijms24054916

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Potential Role of MiRs-139-5p and -454-3p in Endoglin-Knockdown-Induced Angiogenic Dysfunction in HUVECsPMID 36902347Read ↗

The ENG/VEGFα Pathway Is Likely Affected by a Nonsense Variant of Endoglin (ENG)/CD105, Causing Hereditary Hemorrhagic Telangiectasia Type 1 (HHT1) in a Chinese Family.Semantic proximity Read ↗

ENDOGLIN Is Dispensable for Vasculogenesis, but Required for Vascular Endothelial Growth Factor-Induced AngiogenesisSemantic proximity Read ↗

Identifying transcriptomic downstream targets of genes commonly mutated in Hereditary Hemorrhagic TelangiectasiaSemantic proximity Read ↗

5'UTR mutations of ENG cause hereditary hemorrhagic telangiectasia.Semantic proximity Read ↗

Identification of Exosomal MicroRNA Signature by Liquid Biopsy in Hereditary Hemorrhagic Telangiectasia Patients.Semantic proximity Read ↗

Global gene expression profiling of telangiectasial tissue from patients with hereditary hemorrhagic telangiectasia.Semantic proximity Read ↗

Overlapping upstream ORFs ending at c.125 lead to reduced Endoglin, contributing to Hereditary Hemorrhagic TelangiectasiaSemantic proximity Read ↗

[Genetic analysis of a family with hereditary hemorrhagic telangiectasia caused by endoglin gene mutation].Semantic proximity Read ↗

Umbilical vein and placental vessels from newborns with hereditary haemorrhagic telangiectasia type 1 genotype are normal despite reduced expression of endoglin.Semantic proximity Read ↗

Endoglin and alk1 as therapeutic targets for hereditary hemorrhagic telangiectasia.Semantic proximity Read ↗

Unveiling Endoglin non canonical regulation: spotlight on the new role of the uPAR pathwaySemantic proximity Read ↗

MEG8 regulates Tissue Factor Pathway Inhibitor 2 (TFPI2) expression in the endotheliumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.