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MET Exon 14 Skipping and Novel Actionable Variants: Diagnostic and Therapeutic Implications in Latin American Non-Small-Cell Lung Cancer Patients.

International journal of molecular sciences - 22 Dec 2024

Rivas Solange, Sepúlveda Romina V, Tapia Ignacio, Estay Catalina, Soto Vicente, Blanco Alejandro, González Evelin, Armisen Ricardo

Abstract excerpt

Targeted therapy indications for actionable variants in non-small-cell lung cancer (NSCLC) have primarily been studied in Caucasian populations, with limited data on Latin American patients. This study utilized a 52-genes next-generation sequencing (NGS) panel to analyze 1560 tumor biopsies from NSCLC patients in Chile, Brazil, and Peru. The RNA sequencing reads and DNA coverage were correlated to improve the...

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Alternative Splicing
Carcinoma, Non-Small-Cell Lung
Crizotinib
HEK293 Cells
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Kinase Inhibitors

Proto-Oncogene Proteins c-met

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PMID: 39769478
DOI: 10.3390/ijms252413715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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