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Article

Mutations in immunodeficiency-related genes may increase the risk of infection after CAR-T-cell therapy: a report of two cases.

BMC infectious diseases - 22 Feb 2023

Wang Di, He Li, Li Chunhui, Xu Menglei, Yu Qiuxia, Almeida Varlene Daniela Fernandes, Que Yimei, Xu Yanjie, Xiao Yi, Li Chunrui

Abstract excerpt

BACKGROUND: Chimeric antigen receptor T-cell therapy (CAR-T) has yielded unprecedented efficacy in B-cell malignancies. With the increasing use of CAR-T-cell therapy, infection has become one of the major concerns after CAR-T-cell infusion. Some patients even develop refractory or recurrent infections, posing challenges in treatment, prophylactic, and monitoring strategies. However, the mechanisms underlying the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Chimeric Antigen

Source

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Identifiers

PMID: 36814216
DOI: 10.1186/s12879-023-08070-w
PMCID: PMC9948332

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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