Article
XRCC8 mutation causes hypersensitivity to PARP inhibition without Homologous recombination repair deficiency.
Mutation research - 1 Jan 2000
Maeda Junko, Haskins Jeremy S, Kato Takamitsu A
Abstract excerpt
PARP inhibitors inflict severe toxicity to homologous recombination (HR) repair deficient cells because DNA damages induced by PARP inhibition result in lethal DNA double strand breaks in the absence of HR repair during DNA replication. PARP inhibitors are the first clinically approved drugs designed for synthetic lethality. The synthetic lethal interaction of PARP inhibitors is not limited to HR repair deficient...
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