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Article

Interactive association of posttraumatic stress disorder, apolipoprotein ε4 genotype, and age on cognitive functioning.

International journal of geriatric psychiatry - 1 Feb 2023

Lawrence Karen A, Rippey Colton S, Welikson Bianca, Pietrzak Robert H, Adams Thomas G

Abstract excerpt

BACKGROUND: The ε4 allele of the apolipoprotein (APOE) gene and posttraumatic stress disorder (PTSD) are associated with cognitive deficits. Both associations may vary depending on age. No previous study has examined a possible three-way interaction between APOE ε4, PTSD, and age on cognitive functioning. METHODS: Data were analyzed from 1244 European-American U.S. military veterans who participated in the 2011...

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Aged
Apolipoprotein E4
Cognition
Cognitive Dysfunction
APOE gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neuropsychological Tests

Stress Disorders, Post-Traumatic

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Open in PubMed Open full text

Identifiers

PMID: 36757293
DOI: 10.1002/gps.5888
PMCID: PMC10168127

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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