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Article

Uncovering the Oxidative Stress Mechanisms and Targets in Alzheimer's Disease by Integrating Phenotypic Screening Data and Polypharmacology Networks.

Journal of Alzheimer's disease : JAD - 1 Jan 2024

Zhou Moran, Jiao Qian, Wu Zengrui, Li Weihua, Liu Guixia, Wang Rui, Tang Yun

Abstract excerpt

Background: The oxidative stress hypothesis is challenging the dominant position of amyloid-β (Aβ) in the field of understanding the mechanisms of Alzheimer's disease (AD), a complicated and untreatable neurodegenerative disease. Objective: The goal of the present study was to uncover the oxidative stress mechanisms causing AD, as well as the potential therapeutic targets and neuroprotective drugs against...

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Identifiers

PMID: 36744334
DOI: 10.3233/JAD-220727

Genes

AVPR1A
ESR1
NR3C1
PGR
SHBG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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