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The E3 ligase RNF5 restricts SARS-CoV-2 replication by targeting its envelope protein for degradation

3 Feb 2023

Abstract excerpt

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a severe global health crisis; its structural protein envelope (E) is critical for viral entry, budding, production, and induction of pathology which makes it a potential target for therapeutics against COVID-19. Here, we find that the E3 ligase RNF5 interacts with and catalyzes...

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PMID: 36737599
DOI: 10.1038/s41392-023-01335-5

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