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Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids

1 Feb 2023

Abstract excerpt

Kidney organoids generated from induced pluripotent stem cells (iPSC) have proven valuable for studies of kidney development, disease, and therapeutic screening. However, specific applications have been hampered by limited expansion capacity, immaturity, off-target cells, and inability to access the apical side. Here, we apply recently developed tubuloid protocols to purify and propagate kidney epithelium from...

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PMID: 36724260
DOI: 10.1073/pnas.2216836120

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