Article
Leptin-deficient ob/ob mice exhibit periodontitis phenotype and altered oral microbiome.
Journal of periodontal research - 1 Apr 2023
Li Zhicong, Zheng Zhichao, Pathak Janak L, Li Hongtao, Wu Gang, Xu Shaofen, Wang Tianqi, Cheng Haoyu, Piao Zhengguo, Jaspers Richard T, Wu Lihong
Abstract excerpt
BACKGROUND AND OBJECTIVE: Leptin-deficient obesity is associated with various systemic diseases including diabetes and low bone mass phenotype. However, the periodontal status of leptin-deficient obese individuals is still unclear. In this study, we aimed to analyze the periodontal status, alveolar bone phenotype, and oral microbiome status in leptin-deficient obese mice (ob/ob mice). METHODS: This study used...
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