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Article

Genome destabilization-associated phenotypes arising as a consequence of therapeutic treatment are suppressed by Olaparib.

PloS one - 1 Jan 2023

Suzuki Mafuka, Fujimori Haruka, Wakatsuki Kakeru, Manaka Yuya, Asai Haruka, Hyodo Mai, Matsuno Yusuke, Kusumoto-Matsuo Rika, Shiroishi Mitsunori, Yoshioka Ken-Ichi

Abstract excerpt

Malignancy is often associated with therapeutic resistance and metastasis, usually arising after therapeutic treatment. These include radio- and chemo-therapies, which cause cancer cell death by inducing DNA double strand breaks (DSBs). However, it is still unclear how resistance to these DSBs is induced and whether it can be suppressed. Here, we show that DSBs induced by camptothecin (CPT) and radiation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36706121
DOI: 10.1371/journal.pone.0281168
PMCID: PMC9882903

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