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Identification of mosquito proteins that differentially interact with alphavirus nonstructural protein 3, a determinant of vector specificity

25 Jan 2023

Abstract excerpt

Chikungunya virus (CHIKV) and the closely related onyong-nyong virus (ONNV) are arthritogenic arboviruses that have caused significant, often debilitating, disease in millions of people. However, despite their kinship, they are vectored by different mosquito subfamilies that diverged 180 million years ago (anopheline versus culicine subfamilies). Previous work indicated that the nonstructural protein 3 (nsP3) of...

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PMID: 36696390
DOI: 10.1371/journal.pntd.0011028

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