Successful Treatment of Large B-Cell Lymphoma in a Child with Compound Heterozygous Mutation in the ATM Gene.

doi:10.3390/ijms24021099

Article

Successful Treatment of Large B-Cell Lymphoma in a Child with Compound Heterozygous Mutation in the ATM Gene.

International journal of molecular sciences - 6 Jan 2023

Czarny Jakub, Andrzejewska Marta, Zając-Spychała Olga, Latos-Grażyńska Elżbieta, Pastorczak Agata, Wypyszczak Kamila, Szczawińska-Popłonyk Aleksandra, Niewiadomska-Wojnałowicz Izabela, Wziątek Agnieszka, Marciniak-Stępak Patrycja, Dopierała Michał, Małdyk Jadwiga, Jończyk-Potoczna Katarzyna, Derwich Katarzyna

Abstract excerpt

Ataxia-telangiectasia (AT) is a multisystemic neurodegenerative inborn error of immunity (IEI) characterized by DNA repair defect, chromosomal instability, and hypersensitivity to ionizing radiation. Impaired DNA double-strand break repair determines a high risk of developing hematological malignancies, especially lymphoproliferative diseases. Poor response to treatment, excessive chemotherapy toxicities, and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Successful Treatment of Large B-Cell Lymphoma in a Child with Compound Heterozygous Mutation in the ATM Gene.

Abstract excerpt

Topics

Related research