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Article

Endothelial cell-derived exosomes boost and maintain repair-related phenotypes of Schwann cells via miR199-5p to promote nerve regeneration.

Journal of nanobiotechnology - 9 Jan 2023

Huang Jinsheng, Zhang Geyi, Li Senrui, Li Jiangnan, Wang Wengang, Xue Jiajia, Wang Yuanyi, Fang Mengyuan, Zhou Nan

Abstract excerpt

BACKGROUND: Schwann cells (SCs) respond to nerve injury by transforming into the repair-related cell phenotype, which can provide the essential signals and spatial cues to promote axonal regeneration and induce target reinnervation. Endothelial cells (ECs) contribute to intraneural angiogenesis contributing to creating a permissive microenvironment. The coordination between ECs and SCs within injury sites is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36624511
DOI: 10.1186/s12951-023-01767-9
PMCID: PMC9827708

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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