Predictive value of p53 and AXL immunostaining for the efficacy of immune checkpoint inhibitor-based therapy after osimertinib treatment in patients with epidermal growth factor-mutant non-small cell lung cancer.

doi:10.1007/s00262-023-03370-1

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Predictive value of p53 and AXL immunostaining for the efficacy of immune checkpoint inhibitor-based therapy after osimertinib treatment in patients with epidermal growth factor-mutant non-small cell lung cancer.

Cancer immunology, immunotherapy : CII - 1 Jun 2023

Morimoto Kenji, Yamada Tadaaki, Sawada Ryo, Azuma Koichi, Goto Yasuhiro, Harada Taishi, Shiotsu Shinsuke, Tamiya Nobuyo, Chihara Yusuke, Takeda Takayuki, Hiranuma Osamu, Hasegawa Isao, Tanaka Satomi, Yoshimura Akihiro, Iwasaku Masahiro, Tokuda Shinsaku, Kim Young Hak, Takayama Koichi

Abstract excerpt

BACKGROUND: Current evidence indicates that immune checkpoint inhibitors (ICIs) have a limited efficacy in patients with lung cancer harboring epidermal growth factor receptor (EGFR) mutations. However, there is a lack of data on the efficacy of ICIs after osimertinib treatment, and the predictors of ICI efficacy are unclear. METHODS: We retrospectively assessed consecutive patients with EGFR-mutant NSCLC who...

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Identifiers

PMID: 36617602
DOI: 10.1007/s00262-023-03370-1
PMCID: PMC10991525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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