Article
Impact on the Clinical Evolution of Patients with COVID-19 Pneumonia and the Participation of the NFE2L2/KEAP1 Polymorphisms in Regulating SARS-CoV-2 Infection.
International journal of molecular sciences - 27 Dec 2022
Soto María Elena, Fuentevilla-Álvarez Giovanny, Palacios-Chavarría Adrián, Vázquez Rafael Ricardo Valdez, Herrera-Bello Héctor, Moreno-Castañeda Lidia, Torres-Paz Yazmín Estela, González-Moyotl Nadia Janet, Pérez-Torres Idalia, Aisa-Alvarez Alfredo, Manzano-Pech Linaloe, Pérez-Torres Israel, Huesca-Gómez Claudia, Gamboa Ricardo
Abstract excerpt
In patients with severe pneumonia due to COVID-19, the deregulation of oxidative stress is present. Nuclear erythroid factor 2 (NRF2) is regulated by KEAP1, and NRF2 regulates the expression of genes such as NFE2L2-KEAP1, which are involved in cellular defense against oxidative stress. In this study, we analyzed the participation of the polymorphisms of NFE2L2 and KEAP1 genes in the mechanisms of damage in lung...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.