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Article

Is the first-trimester combined screening result associated with the phenotype of Down syndrome? A population-based cohort study.

Prenatal diagnosis - 1 Jan 2023

Steffensen Ellen Hollands, Pedersen Lars Henning, Lou Stina, Vogel Ida

Abstract excerpt

OBJECTIVE: To investigate if the Down syndrome phenotype differs according to the result of first-trimester combined screening (FTS). METHOD: We included all Down syndrome cases diagnosed by karyotype in pregnancy or after birth in Denmark during 2005-2018. We compared screen positive (odds ≥1:300) and screen negative (odds <1:300) cases as well as screen result subgroups with respect to anthropometrics,...

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Source

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Identifiers

PMID: 36471906
DOI: 10.1002/pd.6284
PMCID: PMC10108102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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