SFTS bunyavirus NSs protein sequestrates mTOR into inclusion bodies and deregulates mTOR‐ULK1 signaling, provoking pro‐viral autophagy

Abstract excerpt

Autophagy is emerging as a critical player in host defense against diverse infections, in addition to its conserved function to maintain cellular homeostasis. Strikingly, some pathogens have evolved strategies to evade, subvert or exploit different steps of the autophagy pathway for their lifecycles. Here, we present a new viral mechanism of manipulating autophagy for its own benefit with severe fever with...

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