Article
High-Throughput Functional Evaluation of MAP2K1 Variants in Cancer.
Molecular cancer therapeutics - 1 Feb 2023
Mizuno Sho, Ikegami Masachika, Koyama Takafumi, Sunami Kuniko, Ogata Dai, Kage Hidenori, Yanagaki Mitsuru, Ikeuchi Hiroshi, Ueno Toshihide, Tanikawa Michihiro, Oda Katsutoshi, Osuga Yutaka, Mano Hiroyuki, Kohsaka Shinji
Abstract excerpt
Activating mutations in mitogen-activated protein kinase kinase 1 (MAP2K1) are involved in a variety of cancers and may be classified according to their RAF dependence. Sensitivity to combined BRAF and MEK treatments is associated with co-mutations of MAP2K1 and BRAF; however, the significance of less frequent MAP2K1 mutations is largely unknown. The transforming potential and drug sensitivity of 100 MAP2K1...
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