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The 8p11 myeloproliferative syndrome: Genotypic and phenotypic classification and targeted therapy

3 Nov 2022

Abstract excerpt

EMS(8p11 myeloproliferative syndrome, EMS) is an aggressive hematological neoplasm with/without eosinophilia caused by a rearrangement of the FGFR1 gene at 8p11-12. It was found that all cases carry chromosome abnormalities at the molecular level, not only the previously reported chromosome translocation and insertion but also a chromosome inversion. These abnormalities produced 17 FGFR1 fusion genes, of which...

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PMID: 36408177
DOI: 10.3389/fonc.2022.1015792

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