Article
Inferring a spatial code of cell-cell interactions across a whole animal body.
PLoS computational biology - 1 Nov 2022
Armingol Erick, Ghaddar Abbas, Joshi Chintan J, Baghdassarian Hratch, Shamie Isaac, Chan Jason, Her Hsuan-Lin, Berhanu Samuel, Dar Anushka, Rodriguez-Armstrong Fabiola, Yang Olivia, O'Rourke Eyleen J, Lewis Nathan E
Abstract excerpt
Cell-cell interactions shape cellular function and ultimately organismal phenotype. Interacting cells can sense their mutual distance using combinations of ligand-receptor pairs, suggesting the existence of a spatial code, i.e., signals encoding spatial properties of cellular organization. However, this code driving and sustaining the spatial organization of cells remains to be elucidated. Here we present a...
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