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IQUB deficiency causes male infertility by affecting the activity of p-ERK1/2/RSPH3

10 Nov 2022

Abstract excerpt

STUDY QUESTION: Can new genetic factors responsible for male infertility be identified, especially for those characterized by asthenospermia despite normal sperm morphology? SUMMARY ANSWER: We identified the novel pathogenetic gene IQ motif and ubiquitin-like domain-containing (IQUB) as responsible for male infertility characterized by asthenospermia, involving sperm radial spoke defects. WHAT IS KNOWN ALREADY:...

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PMID: 36355624
DOI: 10.1093/humrep/deac244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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