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Article

RNASeq profiling of COVID19‐infected patients identified an EIF2AK2 inhibitor as a potent SARS‐CoV‐2 antiviral

1 Nov 2022

Abstract excerpt

Dear Editor, In this study, we found gene expression changes in key genes involved in activating immune pathways and genes targeted by SARS-CoV-2 to interfere with normal host cell functioning. Notably, critical changes have been observed in Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2 (EIF2AK2), which plays an important role in activating the interferon response and interfering with host cell...

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PMID: 36321336
DOI: 10.1002/ctm2.1098

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