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SARS-CoV-2 Omicron variant is attenuated for replication in a polarized human lung epithelial cell model

27 Oct 2022

Abstract excerpt

SARS-CoV-2 and its emerging variants of concern remain a major threat for global health. Here we introduce an infection model based upon polarized human Alveolar Epithelial Lentivirus immortalized (hAELVi) cells grown at the air-liquid interface to estimate replication and epidemic potential of respiratory viruses in the human lower respiratory tract. hAELVI cultures are highly permissive for different human...

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PMID: 36302956
DOI: 10.1038/s42003-022-04068-3

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