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Article

Virtual Drug Repositioning as a Tool to Identify Natural Small Molecules That Synergize with Lumacaftor in F508del-CFTR Binding and Rescuing.

International journal of molecular sciences - 14 Oct 2022

Fossa Paola, Uggeri Matteo, Orro Alessandro, Urbinati Chiara, Rondina Alessandro, Milanesi Maria, Pedemonte Nicoletta, Pesce Emanuela, Padoan Rita, Ford Robert C, Meng Xin, Rusnati Marco, D'Ursi Pasqualina

Abstract excerpt

Cystic fibrosis is a hereditary disease mainly caused by the deletion of the Phe 508 (F508del) of the cystic fibrosis transmembrane conductance regulator (CFTR) protein that is thus withheld in the endoplasmic reticulum and rapidly degraded by the ubiquitin/proteasome system. Cystic fibrosis remains a potentially fatal disease, but it has become treatable as a chronic condition due to some CFTR-rescuing drugs...

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Identifiers

PMID: 36293130
DOI: 10.3390/ijms232012274
PMCID: PMC9602983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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