Article
The Genetic Architecture of Vascular Anomalies: Current Data and Future Therapeutic Perspectives Correlated with Molecular Mechanisms.
International journal of molecular sciences - 13 Oct 2022
Butnariu Lăcrămioara Ionela, Gorduza Eusebiu Vlad, Florea Laura, Țarcă Elena, Moisă Ștefana Maria, Trandafir Laura Mihaela, Stoleriu Simona, Bădescu Minerva Codruța, Luca Alina-Costina, Popa Setalia, Radu Iulian, Cojocaru Elena
Abstract excerpt
Vascular anomalies (VAs) are morphogenesis defects of the vascular system (arteries, capillaries, veins, lymphatic vessels) singularly or in complex combinations, sometimes with a severe impact on the quality of life. The progress made in recent years with the identification of the key molecular pathways (PI3K/AKT/mTOR and RAS/BRAF/MAPK/ERK) and the gene mutations that lead to the appearance of VAs has allowed...
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