Article
H7N9 bearing a mutation in the nucleoprotein leads to increased pathology in chickens.
Frontiers in immunology - 1 Jan 2022
Layton Daniel S, Butler Jeffrey, Stewart Cameron, Stevens Vicky, Payne Jean, Rootes Christina, Deffrasnes Celine, Walker Som, Shan Songhua, Gough Tamara J, Cowled Christopher, Bruce Kerri, Wang Jianning, Kedzierska Katherine, Wong Frank Y K, Bean Andrew G D, Bingham John, Williams David T
Abstract excerpt
The zoonotic H7N9 avian influenza (AI) virus first emerged in 2013 as a low pathogenic (LPAI) strain, and has repeatedly caused human infection resulting in severe respiratory illness and a mortality of ~39% (>600 deaths) across five epidemic waves. This virus has circulated in poultry with little to no discernible clinical signs, making detection and control difficult. Contrary to published data, our group has...
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