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Host transcriptional responses in nasal swabs identify potential SARS-CoV-2 infection in PCR negative patients

7 Oct 2022

Abstract excerpt

We analyzed RNA sequencing data from nasal swabs used for SARS-CoV-2 testing. 13% of 317 PCR-negative samples contained over 100 reads aligned to multiple regions of the SARS-CoV-2 genome. Differential gene expression analysis compares the host gene expression in potential false-negative (FN: PCR negative, sequencing positive) samples to subjects with multiple SARS-CoV-2 viral loads. The host transcriptional...

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PMID: 36246576
DOI: 10.1016/j.isci.2022.105310

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