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Article

Effects of chloroquine and hydroxychloroquine on the sensitivity of pancreatic cancer cells to targeted therapies.

Advances in biological regulation - 1 Jan 2023

McCubrey James A, Abrams Stephen L, Follo Matilde Y, Manzoli Lucia, Ratti Stefano, Martelli Alberto M, Cervello Melchiorre

Abstract excerpt

Approaches to improve pancreatic cancer therapy are essential as this disease has a very bleak outcome. Approximately 80% of pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC). PDAC is a cancer which is difficult to effectively treat as it is often detected late in the disease process. Almost all PDACs (over 90%) have activating mutations in the GTPase gene KRAS. These mutations result in...

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36243652
DOI: 10.1016/j.jbior.2022.100917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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