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Article

FOXC2 Promotes Vasculogenic Mimicry in Ovarian Cancer

4 Oct 2022

Abstract excerpt

FOXC2 is a forkhead family transcription factor that plays a critical role in specifying mesenchymal cell fate during embryogenesis. FOXC2 expression is associated with increased metastasis and poor survival in various solid malignancies. Using in vitro and in vivo assays in mouse ovarian cancer cell lines, we confirmed the previously reported mechanisms by which FOXC2 could promote cancer growth, metastasis, and...

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PMID: 36230774
DOI: 10.3390/cancers14194851

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