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Identification of immune-related endoplasmic reticulum stress genes in sepsis using bioinformatics and machine learning

20 Sept 2022

Abstract excerpt

Background: Sepsis-induced apoptosis of immune cells leads to widespread depletion of key immune effector cells. Endoplasmic reticulum (ER) stress has been implicated in the apoptotic pathway, although little is known regarding its role in sepsis-related immune cell apoptosis. The aim of this study was to develop an ER stress-related prognostic and diagnostic signature for sepsis through bioinformatics and...

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PMID: 36203606
DOI: 10.3389/fimmu.2022.995974

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