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Screening of candidate genes at GLC3B and GLC3C loci in Chinese primary congenital glaucoma patients with targeted next generation sequencing.

Ophthalmic genetics - 1 Apr 2023

Qiao Yunsheng, Shao Tingting, Chen Yuhong, Chen Junyi, Sun Xinghuai, Chen Xueli

Abstract excerpt

BACKGROUND: Primary congenital glaucoma (PCG) is characterized by developmental abnormalities of the anterior chamber angle. Although several genes have been associated with PCG, pathogenic mutations could only be detected in about 20% of Chinese patients. GLC3B (1p36.2-36.1) and GLC3C (14q24.3) loci were previously identified in PCG pedigrees via linkage analysis. However, no causative genes were reported in...

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PMID: 36193031
DOI: 10.1080/13816810.2022.2109683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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