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SARS-CoV-2 Spike protein S2 subunit modulates γ-secretase and enhances amyloid-β production in COVID-19 neuropathy

30 Sept 2022

Abstract excerpt

SARS-CoV-2-induced multi-lineage neural cell dysregulation has been documented 1 . SARS-CoV-2 infection elevates neuroinflammation 2 , alters brain structure 3 leads to abnormal accumulation of neurodegenerative amyloid-β (Aβ) and phosphorylated tau 4 , 5 , and increases the risk of cognitive impairment 6 in COVID-19 patients. However, the mechanism underlying neurological dysfunctions following SARS-CoV-2...

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PMID: 36180433
DOI: 10.1038/s41421-022-00458-3

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