Article
Hepatitis C subtyping assay failure in UK patients born in sub-Saharan Africa: Implications for global treatment and elimination.
Journal of medical virology - 1 Jan 2023
Adeboyejo Kazeem, King Barnabas J, Tsoleridis Theocharis, Tarr Alexander W, McLauchlan John, Irving William L, Ball Jonathan K, McClure C Patrick
Abstract excerpt
BACKGROUND AND AIMS: The newly developed direct-acting antivirals have revolutionized the treatment of chronic hepatitis C virus (HCV), with cure rates as high as 98% in some cohorts. Although genome sequencing has demonstrated that some subtypes of HCV naturally harbor drug resistance associated substitutions (RAS), these are often overlooked as "rarities." Furthermore, commercial subtyping assays and associated...
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