Back to search

Article

Hepatitis C subtyping assay failure in UK patients born in Sub-Saharan Africa: implications for global treatment and elimination

2021-12-15

Abstract excerpt

The newly developed direct-acting antivirals (DAAs) have revolutionised the treatment of chronic hepatitis C virus (HCV), where cohort studies have shown that cure rates as high as 98% can be achieved. Whilst genome sequencing has demonstrated that some subtypes of HCV naturally harbour drug resistance associated substitutions (RAS), these have not been considered important as previous molecular epidemiological st...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5d5bf6e3-a932-5454-800f-5913adfdbb83
DOI
10.1101/2021.12.14.21267714
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Hepatitis C subtyping assay failure in UK patients born in Sub-Saharan Africa: implications for global treatment and eliminationDOI 10.1101/2021.12.14.21267714
Hepatitis C subtyping assay failure in UK patients born in sub-Saharan Africa: Implications for global treatment and elimination.Semantic proximity
Highly Diverse Hepatitis C Strains Detected in Sub‐Saharan Africa Have Unknown Susceptibility to Direct‐Acting Antiviral TreatmentsSemantic proximity
Real-World Outcomes of Direct-Acting Antiviral Treatment and Retreatment in United Kingdom-Based Patients Infected With Hepatitis C Virus Genotypes/Subtypes Endemic in Africa.Semantic proximity
HCV Diagnosis and Sequencing Using Dried Blood Spots from Patients in Kinshasa (DRC): A Tool to Achieve WHO 2030 TargetsSemantic proximity
Hepatitis C virus genotype homogeneity and lack of major Sofosbuvir resistance-associated substitutions among blood donors in EthiopiaSemantic proximity
Hepatitis C in sub-Saharan Africa: the current status and recommendations for achieving elimination by 2030.Semantic proximity
Suboptimal SVR rates in African patients with atypical genotype 1 subtypes: Implications for global elimination of hepatitis CSemantic proximity
Hepatitis C genotype distribution in patient and blood donor samples in South Africa for the period 2008-2012.Semantic proximity
Naturally occurring resistance mutations within the core and NS5B regions in hepatitis C genotypes, particularly genotype 5a, in South Africa.Semantic proximity
A systematic review of Hepatitis B virus (HBV) drug and vaccine escape mutations in Africa: a call for urgent actionSemantic proximity
An Oxford Nanopore Technology-Based Hepatitis B Virus Sequencing Protocol Suitable For Genomic Surveillance Within Clinical Diagnostic SettingsSemantic proximity
A decade-long retrospective study of hepatitis C virus genetic diversity in Cameroon, 2013-2023: presence of a high proportion of unsubtypable and putative recombinant HCV strains.Semantic proximity
Select a neighboring publication to make it the new centre.