Article
Risk factors for difficult-to-treat hepatitis C virus genotype 4r in Rwanda and implications for elimination in sub-Saharan Africa.
Journal of viral hepatitis - 1 Apr 2021
Shumbusho Fabienne, Liu Anne F, Kateera Fredrick, Kabahizi Jules, Nsanzaimana Sabin, Serumondo Janvier, Damascene Makuza Jean, Grant Philip M, Musabeyezu Emmanuel, Muvunyi Claude, Gupta Neil
Abstract excerpt
In sub-Saharan Africa, there exist distinct HCV genotype (GT) subtypes harbouring resistance-associated substitutions to commonly used non-structural protein 5A (NS5A) inhibitor-based direct-acting antiviral (DAA) regimens. In particular, GT4r subtype has demonstrated high rates of treatment failure. In the absence of routine viral sequencing in sub-Saharan Africa, it is important to identify sociodemographic,...
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