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Article

The conservation of human functional variants and their effects across livestock species.

Communications biology - 21 Sept 2022

Zhao Rongrong, Talenti Andrea, Fang Lingzhao, Liu Shuli, Liu George, Chue Hong Neil P, Tenesa Albert, Hassan Musa, Prendergast James G D

Abstract excerpt

Despite the clear potential of livestock models of human functional variants to provide important insights into the biological mechanisms driving human diseases and traits, their use to date has been limited. Generating such models via genome editing is costly and time consuming, and it is unclear which variants will have conserved effects across species. In this study we address these issues by studying...

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Identifiers

PMID: 36131008
DOI: 10.1038/s42003-022-03961-1
PMCID: PMC9492664

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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