Article
Genetic risk and incident venous thromboembolism in middle-aged and older adults following COVID-19 vaccination.
Journal of thrombosis and haemostasis : JTH - 1 Dec 2022
Xie Junqing, Prats-Uribe Albert, Gordillo-Marañón Maria, Strauss Victoria Y, Gill Dipender, Prieto-Alhambra Daniel
Abstract excerpt
BACKGROUND: COVID-19 vaccination has been associated with increased venous thromboembolism (VTE) risk. However, it is unknown whether genetic predisposition to VTE is associated with an increased risk of thrombosis following vaccination. METHODS: Using data from the UK Biobank, which contains in-depth genotyping and linked vaccination and health outcomes information, we generated a polygenic risk score (PRS)...
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