CHD5 gene (rs9434741) might be a genetic risk factor for infertility in non-obstructive azoospermia and severe oligozoospermia.

doi:10.1111/and.14590

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Article

CHD5 gene (rs9434741) might be a genetic risk factor for infertility in non-obstructive azoospermia and severe oligozoospermia.

Andrologia - 1 Dec 2022

Naeimi Nasim, Mohseni Kouchesfehani Homa, Heidari Zahra, Mahmoudzadeh-Sagheb Hamidreza, Movahed Saeed

Abstract excerpt

Inability to conceive is one of the health concerns. Chromodomain helicase DNA-binding protein5 (CHD5) gene is a major regulator in the replacement of histone proteins with protamines, the chromatin remodelling in spermatogenesis process. Thus, functional SNPs in this gene can disrupt sperm development. This study aimed to investigate the relationship between CHD5 polymorphism (rs9434741) and male infertility....

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PMID: 36102082
DOI: 10.1111/and.14590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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