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Article

Transplantation of PSC-derived myogenic progenitors counteracts disease phenotypes in FSHD mice

2 Sept 2022

Abstract excerpt

Facioscapulohumeral muscular dystrophy (FSHD) is a genetically dominant progressive myopathy caused by improper silencing of the DUX4 gene, leading to fibrosis, muscle atrophy, and fatty replacement. Approaches focused on muscle regeneration through the delivery of stem cells represent an attractive therapeutic option for muscular dystrophies. To investigate the potential for cell transplantation in FSHD, we have...

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PMID: 36056021
DOI: 10.1038/s41536-022-00249-0

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