Article
An Atypical Presentation of Upper Motor Neuron Predominant Juvenile Amyotrophic Lateral Sclerosis Associated with TARDBP Gene: A Case Report and Review of the Literature.
Genes - 19 Aug 2022
Sánchez-Tejerina Daniel, Restrepo-Vera Juan Luis, Rovira-Moreno Eulalia, Codina-Sola Marta, Llauradó Arnau, Sotoca Javier, Salvado Maria, Raguer Núria, García-Arumí Elena, Juntas-Morales Raúl
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that can rarely affect young individuals. Juvenile ALS (JALS) is defined for individuals with an onset of the disease before the age of 25. The contribution of genetics to ALS pathology is a field of growing interest. One of the differences between adult-onset ALS and JALS is their genetic background, with a higher contribution of genetic causes...
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